Pre-defense of the thesis by D.Manapkyzy

On November 29, 2024, the pre-defense of the thesis of Doctor of Philosophy (PhD) Manapkyzy Diana on the theme «Study of the aberrant excision repair pathway initiated by Thymine-DNA glycosylase (TDG) in living cells» on the educational program «8D05104 - Genetics» was held.

This thesis studies the molecular mechanisms of the aberrant DNA repair pathway initiated by thymine DNA glycosylase (TDG), an enzyme involved in the base excision repair (BER) pathway. The study includes biochemical and genetic evaluation of TDG activity on model DNA damage in vitro and in vivo. The study's results significantly contribute to understanding the molecular mechanisms of TDG action, its involvement in the maintenance of genomic stability, the regulation of gene expression, and epigenetic modifications. These data open up prospects for developing new therapeutic approaches to treat diseases associated with BER dysfunction, including neurodegenerative and oncological pathologies, as well as the development of TDG inhibitors that may form the basis of new anti-cancer therapeutic strategies.

The thesis also examines the aspects of the 3 sustainable development goals (SDGs) «Good Health and Well-being».

Department of Molecular Biology and Genetics